1Q: which of these statements is not correct ?
A. Neomycin is used as a preservative for BCG
B. kanamycin is use as a preservative for measles
C. magnesium chloride is used as a stabilizer for OPV
D. thimerosal is used as a preservative for DPT
answer: A .
let us analyse the options one by one
NEOMYCIN IS USED AS A PRESERVATIVE FOR BCG
The statement is FALSE
BCG contains glycerine, asparagine, citric acid, potassium phosphate, magnesium sulphate, and iron ammonium citrate. The final preparation prior to freeze-drying also contains lactose.
Sodium glutamate and chloride are also used as preservatives.
There is no neomycin
KANAMYCIN IS USE AS A PRESERVATIVE FOR MEASLES
The statement is TRUE
Yes , measles vaccine contains the antibiotics erythromycin and kanamycin.
Therefore , “kanamycin allergy is a definite contra indication to the measles vaccine ”
MAGNESIUM CHLORIDE IS USED AS A STABILISER IN OPV
That’s TRUE
Also remember
“Injectable polio vaccines do contain the antibiotics neomycin , streptomycin and polymyxin B but not oral polio vaccine !!! ”
Who knows …… this might be the question of 2009 !
THIMEROSAL IS USED AS A PRESERVATIVE IN DPT
YES that’s also true.
Thimerosal is a mercury derivative and hence raising a lot of controversies. It is used in certain other vaccines too.
WHAT IS SO CONTROVERSIAL ABOUT IT ?
Statistics indicate that AUTISM is on the rise. Researchers say that the use of thimerosal in several vaccines, especially DPT is directly related to the rise in autism !!!!
Composition of vaccines :
DPT: Aluminium phosphate, formaldehyde, ammonium sulphate, washed sheep red blood cells, glycerol, sodium chloride, thimerosal
Polio:
IPOL: 3 types of polio
virus, formaldehyde, henoxyethanol (antifreeze), neomycin, streptomycin, polymyxin B;
Orimune: using 3 types of attenuated polioviruses, streptomycin, neomycin, calf serum, sorbitol
HIB: polyribosylribitol, ammonium sulfate, thimerosal.
MMR: sorbitol, neomycin, hydrolyzed gelatin.
BCG: glycerine, asparagine, citric acid, potassium phosphate, magnesium sulphate, and iron ammonium citrate. The final preparation prior to freeze-drying also contains lactose.
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